Expert: Drug-resistant tuberculosis is difficult to prevent and control and requires long-term standardized treatment

Expert: Drug-resistant tuberculosis is difficult to prevent and control and requires long-term standardized treatment


Tuberculosis, commonly known as “tuberculosis”, is a chronic infectious disease caused by Mycobacterium tuberculosis infection. The 29th “World Tuberculosis Day” is approaching. Professor Sha Wei, director of the Tuberculosis Department of Shanghai Pulmonary Hospital Affiliated to Tongji University, said in an interview with a reporter from China News Service on the 22nd that tuberculosis is no longer a frightening “infectious disease”. “Terminal disease”, the cause is clear, preventable and curable, and the cure rate is constantly improving.

Among tuberculosis, drug-resistant tuberculosis is a difficulty in tuberculosis prevention and control in China. The tuberculosis bacilli infected by the patient are resistant to one or more anti-tuberculosis drugs, which is called drug-resistant tuberculosis. When resistance to two of the most effective first-line drugs for TB treatment, isoniazid and rifampicin, occurs, it is called multidrug-resistant TB.

“Partially drug-resistant tuberculosis occurs because tuberculosis patients are not treated in a standardized manner. For example, patients do not complete the full course of treatment, are treated irregularly, have inappropriate treatment plans, and have poor drug quality, etc., thus developing resistance to anti-tuberculosis drugs,” Sha said. Professor Wei pointed out, “Some patients have lived in areas with a high prevalence of drug-resistant tuberculosis, or have been in contact with patients diagnosed with drug-resistant tuberculosis, and have been directly infected with drug-resistant tuberculosis bacilli, and may also be diagnosed with drug-resistant tuberculosis at the time of initial diagnosis. .”

Professor Sha Wei explained that the cure rate of drug-resistant tuberculosis is much lower than that of ordinary tuberculosis; tuberculosis patients are sources of infection before they receive effective treatment, because drug-resistant tuberculosis patients spread drug-resistant tuberculosis bacilli, which is more harmful than ordinary tuberculosis. Tuberculosis patients need to be older.

“For patients with drug-resistant pulmonary tuberculosis, especially multi-drug-resistant pulmonary tuberculosis, early detection, early diagnosis, and early treatment are very critical.” Professor Sha Wei said, “The clinical application of new diagnostic technologies such as molecular testing can help patients recover within a day. The diagnosis of drug resistance can be completed within a short period of time, greatly improving the diagnostic efficiency. At the same time, after a patient is diagnosed with multi-drug-resistant tuberculosis, it is necessary to choose an effective treatment plan as early as possible in order to avoid recurrence and infection, control the development of the disease, and achieve early treatment, early cure, and early recovery. beneficial.”

“We can prevent tuberculosis in our daily life, and actively develop good personal hygiene habits, avoid spitting, ventilate frequently, and maintain a regular work and rest schedule.” Professor Sha Wei emphasized, “If a cough lasts for more than two weeks, especially if it is accompanied by If you have sputum, blood-streaked sputum, unexplained fever, or significant weight loss, you should consider the possibility of tuberculosis and seek medical attention as soon as possible for detailed tuberculosis screening to avoid the worsening and spread of the disease.”

The expert said: “Tuberculosis patients may also experience symptoms such as low-grade fever, fatigue, night sweats, loss of appetite, and weight loss. Mycobacterium tuberculosis can be spread through the air when an infected person coughs, sneezes, or spits.”

She told reporters that tuberculosis affects high-risk groups. People with low immunity (including those with underlying diseases or those who need to take immune preparations), the elderly, malnourished people, and people with diabetes are also more likely to get tuberculosis. These patients are advised to Get regular physical exams and screenings.

It is reported that the theme of this year’s World Tuberculosis Day is “You and I work together to end the tuberculosis epidemic.” How to avoid the emergence of drug-resistant tuberculosis? Professor Sha Wei pointed out that we must first strengthen patient education, popularize knowledge about tuberculosis, and let them realize the importance of long-term standardized treatment. They should not think that the disease will be cured when symptoms are gone; innovation in drugs and treatment plans in the field of tuberculosis must be promoted to greatly improve Shorten the course of treatment. She revealed: “Currently we are also conducting relevant clinical research.”


Source link